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KMID : 0380519970010010001
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Korean Journal of Veterinary Pathology
1997 Volume.1 No. 1 p.1 ~ p.6
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Regeneration of Immune System after Syngeneic Bone Marrow Transplantation in Irradiated Mice: I. The Changes of Cell Number in Peripheral blood and Lymphatic Organs and Composition of Lymphocyte Subsets
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Kim Seong-Ho
Oh Heon
Lee Song-Eun
Kim Soon-Tae
Jo Sung-Kee
Hyun Byung-Hwa
Ryu Si-Yun
Daynes Raymond A.
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Abstract
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The cellularity and composition of the spleen lymph node thymus and peripheral blood and tempo of regeneration were studied at various time points after syngeneic bone marrow transplantation(BMT) in C3H/Hen mice. Significant depression of absolute lymphocyte count was noted on week 1 after lethal whole-body irradiation and BMT. In comparison to the lymph node thymus and spleen had an rapid regeneration of cellularity. The distinct cell populations($CD4+, CD8+, CD28+, B220+) have determined in the lymphoid tissue of mice subjected to irradiation. The relative representation of these subpopulations was significantly different from that in nonirradiated control. CD4+ and CD8+ cells were present in very low numbers whereas the B220+ cells reached more than normal range at 2 weeks after BMT. The number of CD4+ cells returned to normal relatively soon than CD8+ cell. At week 4 after BMT, the cellularity and composition of spleen lymph node and peripheral blood lymphocyte reached about 50% of the normal range therefore we can choose this time point for the other tests of immune function after BMT.
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KEYWORD
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Lymphocyte subsets, mouse, regeneration of immune cell, syngeneic bone marrow transplantation
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